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KMID : 0604520160420030203
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Journal of the Society of Cosmetic Scientists of Korea
2016 Volume.42 No. 3 p.203 ~ p.209
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Hair Growth-promoting Effect of Resina Pini and Its Main Constituent, Abietic Acid, in Mouse Model of Alopecia
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Park Gun-Hyuk
Kim Yong-Ung
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Abstract
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Recently, increased attention has been directed toward medicinal extracts and their active ingredients as potential new drug candidates for androgenic alopecia. Resina Pini (RP), a resinous exudation obtained from Pinus sp. (Pinaceae), has been used as a traditional medicine for the treatment of infection, pain related to dental caries, and periodontal disease. Previously, we suggested that RP and its main constituent, abietic acid (abieta-7,13-dien-18-oic acid; AA), may play important roles against androgenic alopecia as 5α-reductase inhibitors. However, to date, there is no evidence that AA has hair growth-promoting effects in vivo. In this study, we found that 10 ∼ 300 mg/kg RP and 3 ∼ 30 mg/kg AA significantly promoted hair growth in a C3H/HeN mouse model of alopecia. To our knowledge, this is the first report of the hair growth-promoting effects of RP and AA in vivo. From these results, RP and its main constituent AA can promote hair growth in mouse by inhibiting 5α-reductase activity and may be effective alternative therapies for androgenic alopecia.
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KEYWORD
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hair growth, Resina Pini, abietic acid, androgenic alopecia, mouse model, 5α-reductase inhibitor
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